Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50208 |
Resumo: | © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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7160 |
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Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cellsCell-cell interactionExtracellular matrix signalingFibronectinMuscle developmentNuclear movementNuclear position© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Skeletal muscle cells (myofibers) are rod-shaped multinucleated cells surrounded by an extracellular matrix (ECM) basal lamina. In contrast to other cell types, nuclei in myofibers are positioned just below the plasma membrane at the cell periphery. Peripheral nuclear positioning occurs during myogenesis and is driven by myofibril crosslinking and contraction. Here we show that peripheral nuclear positioning is triggered by local accumulation of fibronectin secreted by myofibroblasts. We demonstrate that fibronectin via α5-integrin mediates peripheral nuclear positioning dependent on FAK and Src activation. Finally, we show that Cdc42, downstream of restricted fibronectin activation, is required for myofibril crosslinking but not myofibril contraction. Thus we identify that local activation of integrin by fibronectin secreted by myofibroblasts activates peripheral nuclear positioning in skeletal myofibers.ElsevierRepositório da Universidade de LisboaRoman, WilliamMartins, João P.Gomes, Edgar2021-11-29T17:21:10Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50208engDev Cell. 2018 Jul 2;46(1):102-111.e61534-580710.1016/j.devcel.2018.05.0311534-5807info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:09Zoai:repositorio.ul.pt:10451/50208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:36.820276Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
title |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
spellingShingle |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells Roman, William Cell-cell interaction Extracellular matrix signaling Fibronectin Muscle development Nuclear movement Nuclear position |
title_short |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
title_full |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
title_fullStr |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
title_full_unstemmed |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
title_sort |
Local arrangement of Fibronectin by myofibroblasts governs peripheral nuclear positioning in muscle cells |
author |
Roman, William |
author_facet |
Roman, William Martins, João P. Gomes, Edgar |
author_role |
author |
author2 |
Martins, João P. Gomes, Edgar |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Roman, William Martins, João P. Gomes, Edgar |
dc.subject.por.fl_str_mv |
Cell-cell interaction Extracellular matrix signaling Fibronectin Muscle development Nuclear movement Nuclear position |
topic |
Cell-cell interaction Extracellular matrix signaling Fibronectin Muscle development Nuclear movement Nuclear position |
description |
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2021-11-29T17:21:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50208 |
url |
http://hdl.handle.net/10451/50208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Dev Cell. 2018 Jul 2;46(1):102-111.e6 1534-5807 10.1016/j.devcel.2018.05.031 1534-5807 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799134564609687552 |