An ASIC for electrical probing of adECM/GBM scaffolds

• Autor(a) principal: Quelhas, Bernardo Bessa
• Data de Publicação: 2021
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10773/33727
• topic: ASIC; Acquisition; Electronics; SCI; Scaffold; Implantable

This dissertation document has the role of explaining how to design and develop an ASIC system. The full system has the objective to resolve a problem named, spinal cord injury, which is, as of today still an incurable illness. Merging a stimulation and an acquisition systems it might be possible to implement a reliable solution. This circuit is a part of the full solution system and has the role to acquire electrical signals at the terminal of the scaffold being tested. This way, it is possible to indirectly determine the impedance value of the scaffold undergoing electrical stimulation. Resulting in a quantitative evaluation of the stimulation performance. For this project, the scaffold proposed is composed of graphene-based materials in combination with human adipose-derived decellularized tissue. Since this circuit is an acquisition system, by itself, it does not have the characteristics to resolve the illness stated above. However, has a secondary circuit, it is capable of complementing the results obtained even more. First a proof of concept was achieved, in the Cadence Spectre, by designing and testing every block individually. Second, a layout was done, with the Cadence Virtuoso, this last process is very important because, with few modifications to the layout, it is possible to create an equivalent system in hardware.