Spectrophotometric determination of cefaclor in pharmaceutical preparations

Detalhes bibliográficos
Autor(a) principal: Ivama,Viviane M.
Data de Publicação: 1999
Outros Autores: Rodrigues,Letícia N. C., Guaratini,Cláudia C. I., Zanoni,Maria Valnice B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000200011
Resumo: A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.
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spelling Spectrophotometric determination of cefaclor in pharmaceutical preparationscefaclorhydrolysispharmaceuticalsA simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.Sociedade Brasileira de Química1999-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000200011Química Nova v.22 n.2 1999reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40421999000200011info:eu-repo/semantics/openAccessIvama,Viviane M.Rodrigues,Letícia N. C.Guaratini,Cláudia C. I.Zanoni,Maria Valnice B.eng2000-05-12T00:00:00Zoai:scielo:S0100-40421999000200011Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2000-05-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Spectrophotometric determination of cefaclor in pharmaceutical preparations
title Spectrophotometric determination of cefaclor in pharmaceutical preparations
spellingShingle Spectrophotometric determination of cefaclor in pharmaceutical preparations
Ivama,Viviane M.
cefaclor
hydrolysis
pharmaceuticals
title_short Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_full Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_fullStr Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_full_unstemmed Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_sort Spectrophotometric determination of cefaclor in pharmaceutical preparations
author Ivama,Viviane M.
author_facet Ivama,Viviane M.
Rodrigues,Letícia N. C.
Guaratini,Cláudia C. I.
Zanoni,Maria Valnice B.
author_role author
author2 Rodrigues,Letícia N. C.
Guaratini,Cláudia C. I.
Zanoni,Maria Valnice B.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ivama,Viviane M.
Rodrigues,Letícia N. C.
Guaratini,Cláudia C. I.
Zanoni,Maria Valnice B.
dc.subject.por.fl_str_mv cefaclor
hydrolysis
pharmaceuticals
topic cefaclor
hydrolysis
pharmaceuticals
description A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.
publishDate 1999
dc.date.none.fl_str_mv 1999-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000200011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000200011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40421999000200011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.22 n.2 1999
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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