Spectrophotometric determination of cefaclor in pharmaceutical preparations

Detalhes bibliográficos
Autor(a) principal: Ivama, Viviane M. [UNESP]
Data de Publicação: 1999
Outros Autores: Rodrigues, Letícia N. C. [UNESP], Guaratini, Cláudia C. I. [UNESP], Zanoni, Maria Valnice Boldrin [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-40421999000200011
http://hdl.handle.net/11449/25705
Resumo: A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.
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spelling Spectrophotometric determination of cefaclor in pharmaceutical preparationscefaclorhydrolysispharmaceuticalsA simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UNESP Instituto de QuímicaUNESP Instituto de QuímicaSociedade Brasileira de QuímicaUniversidade Estadual Paulista (Unesp)Ivama, Viviane M. [UNESP]Rodrigues, Letícia N. C. [UNESP]Guaratini, Cláudia C. I. [UNESP]Zanoni, Maria Valnice Boldrin [UNESP]2014-05-20T14:18:56Z2014-05-20T14:18:56Z1999-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article201-204http://dx.doi.org/10.1590/S0100-40421999000200011Química Nova. Sociedade Brasileira de Química, v. 22, n. 2, p. 201-204, 1999.0100-4042http://hdl.handle.net/11449/2570510.1590/S0100-40421999000200011S0100-404219990002000110000-0002-2296-1393SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2021-10-23T11:51:49Zoai:repositorio.unesp.br:11449/25705Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:39:31.582758Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Spectrophotometric determination of cefaclor in pharmaceutical preparations
title Spectrophotometric determination of cefaclor in pharmaceutical preparations
spellingShingle Spectrophotometric determination of cefaclor in pharmaceutical preparations
Ivama, Viviane M. [UNESP]
cefaclor
hydrolysis
pharmaceuticals
title_short Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_full Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_fullStr Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_full_unstemmed Spectrophotometric determination of cefaclor in pharmaceutical preparations
title_sort Spectrophotometric determination of cefaclor in pharmaceutical preparations
author Ivama, Viviane M. [UNESP]
author_facet Ivama, Viviane M. [UNESP]
Rodrigues, Letícia N. C. [UNESP]
Guaratini, Cláudia C. I. [UNESP]
Zanoni, Maria Valnice Boldrin [UNESP]
author_role author
author2 Rodrigues, Letícia N. C. [UNESP]
Guaratini, Cláudia C. I. [UNESP]
Zanoni, Maria Valnice Boldrin [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ivama, Viviane M. [UNESP]
Rodrigues, Letícia N. C. [UNESP]
Guaratini, Cláudia C. I. [UNESP]
Zanoni, Maria Valnice Boldrin [UNESP]
dc.subject.por.fl_str_mv cefaclor
hydrolysis
pharmaceuticals
topic cefaclor
hydrolysis
pharmaceuticals
description A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.
publishDate 1999
dc.date.none.fl_str_mv 1999-04-01
2014-05-20T14:18:56Z
2014-05-20T14:18:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40421999000200011
Química Nova. Sociedade Brasileira de Química, v. 22, n. 2, p. 201-204, 1999.
0100-4042
http://hdl.handle.net/11449/25705
10.1590/S0100-40421999000200011
S0100-40421999000200011
0000-0002-2296-1393
url http://dx.doi.org/10.1590/S0100-40421999000200011
http://hdl.handle.net/11449/25705
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 22, n. 2, p. 201-204, 1999.
0100-4042
10.1590/S0100-40421999000200011
S0100-40421999000200011
0000-0002-2296-1393
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 201-204
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129102021918720

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