Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: Teixeira, Leonardo Sena Gomes
Data de Publicação: 2011
Outros Autores: Teixeira, Maiana de Araujo, Bueno, Admar Jorge Machado, Brito, Cristiane F. de, Dantas, Alailson Falcão, Costa, Antonio Celso Spinola
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14777
Resumo: p. 1198–1201
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spelling Teixeira, Leonardo Sena GomesTeixeira, Maiana de AraujoBueno, Admar Jorge MachadoBrito, Cristiane F. deDantas, Alailson FalcãoCosta, Antonio Celso Spinola2014-03-31T13:08:45Z2014-03-31T13:08:45Z20111759-9660http://repositorio.ufba.br/ri/handle/ri/14777v. 3, n. 5p. 1198–1201Three nitroanilines (2-methoxy-4-nitroaniline, 2,4-dinitroaniline and 2-methyl-4-nitroaniline) were tested as spectrophotometric reagents for determination of ethinylestradiol (ETE). The determinations were based on absorbance measurments of the reaction product obtained from the coupling of each diazotized nitroaniline with ETE. Optimization of temperature, pH and diazotization coupling reaction time was realized. 2-Methyl-4-nitroaniline provided the more sensitive system for ETE spectrophotometric determination at 531 nm and the analytical response was linear in the concentration range of 0.65–10.0 µg ml−1. The limit of detection and coefficient of variation were estimated as 197 µg l−1 and 4.5%, respectively. The results showed that the proposed method is simple and rapid, allowing selective determination of analyte. The method successfully determined ETE in oral contraceptive formulations.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-03-31T13:08:45Z No. of bitstreams: 1 Leonardo S. G. Teixeira.pdf: 117575 bytes, checksum: 59b3c427bd217964a46c3e862a9dc6da (MD5)Made available in DSpace on 2014-03-31T13:08:45Z (GMT). No. of bitstreams: 1 Leonardo S. G. Teixeira.pdf: 117575 bytes, checksum: 59b3c427bd217964a46c3e862a9dc6da (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1039/C0AY00783Hreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAUse of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulationsAnalytical Methodsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessporLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14777/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALLeonardo S. G. Teixeira.pdfLeonardo S. G. Teixeira.pdfapplication/pdf117575https://repositorio.ufba.br/bitstream/ri/14777/1/Leonardo%20S.%20G.%20Teixeira.pdf59b3c427bd217964a46c3e862a9dc6daMD51TEXTLeonardo S. G. Teixeira.pdf.txtLeonardo S. G. Teixeira.pdf.txtExtracted texttext/plain18298https://repositorio.ufba.br/bitstream/ri/14777/3/Leonardo%20S.%20G.%20Teixeira.pdf.txtb342023e752f38594bc867c680f7c754MD53ri/147772022-03-23 20:19:33.142oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-23T23:19:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
dc.title.alternative.pt_BR.fl_str_mv Analytical Methods
title Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
spellingShingle Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
Teixeira, Leonardo Sena Gomes
title_short Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
title_full Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
title_fullStr Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
title_full_unstemmed Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
title_sort Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
author Teixeira, Leonardo Sena Gomes
author_facet Teixeira, Leonardo Sena Gomes
Teixeira, Maiana de Araujo
Bueno, Admar Jorge Machado
Brito, Cristiane F. de
Dantas, Alailson Falcão
Costa, Antonio Celso Spinola
author_role author
author2 Teixeira, Maiana de Araujo
Bueno, Admar Jorge Machado
Brito, Cristiane F. de
Dantas, Alailson Falcão
Costa, Antonio Celso Spinola
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira, Leonardo Sena Gomes
Teixeira, Maiana de Araujo
Bueno, Admar Jorge Machado
Brito, Cristiane F. de
Dantas, Alailson Falcão
Costa, Antonio Celso Spinola
description p. 1198–1201
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-03-31T13:08:45Z
dc.date.available.fl_str_mv 2014-03-31T13:08:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14777
dc.identifier.issn.none.fl_str_mv 1759-9660
dc.identifier.number.pt_BR.fl_str_mv v. 3, n. 5
identifier_str_mv 1759-9660
v. 3, n. 5
url http://repositorio.ufba.br/ri/handle/ri/14777
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1039/C0AY00783H
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