Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5417 |
Resumo: | p. e1169. |
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Tavares, Natália MachadoSilva, Robson A.Costa, Dirceu JoaquimPitombo, Maiana A.Fukutani, Kiyoshi FerreiraMiranda, José C.Valenzuela, Jesus G.Barral, Aldina Maria PradoOliveira, Camila Indiani deBarral-Netto, ManoelBrodskyn, Claudia IdaTavares, Natália MachadoSilva, Robson A.Costa, Dirceu JoaquimPitombo, Maiana A.Fukutani, Kiyoshi FerreiraMiranda, José C.Valenzuela, Jesus G.Barral, Aldina Maria PradoOliveira, Camila Indiani deBarral-Netto, ManoelBrodskyn, Claudia Ida2012-02-14T12:03:45Z2012-02-14T12:03:45Z20111935-2727http://www.repositorio.ufba.br/ri/handle/ri/5417v. 5, n. 5.p. e1169.Background: Leishmania transmission occurs in the presence of insect saliva. Immunity to Phlebotomus papatasi or Lutzomyia longipalpis saliva or salivary components confers protection against an infection by Leishmania in the presence of the homologous saliva. However, immunization with Lutzomyia intermedia saliva did not protect mice against Leishmania braziliensis plus Lu. intermedia saliva. In the present study, we have studied whether the immunization with Lu. longipalpis saliva or a DNA plasmid coding for LJM19 salivary protein would be protective against L. braziliensis infection in the presence of Lu. intermedia saliva, the natural vector for L. braziliensis. Methodology/Principal Findings: Immunization with Lu. longipalpis saliva or with LJM19 DNA plasmid induced a Delayed-Type Hypersensitivity (DTH) response against Lu. longipalpis as well as against a Lu. intermedia saliva challenge. Immunized and unimmunized control hamsters were then intradermally infected in the ears with L. braziliensis in the presence of Lu. longipalpis or Lu. intermedia saliva. Animals immunized with Lu. longipalpis saliva exhibited smaller lesion sizes as well as reduced disease burdens both at lesion site and in the draining lymph nodes. These alterations were associated with a significant decrease in the expression levels of IL-10 and TGF-b. Animals immunized with LJM19 DNA plasmid presented similar findings in protection and immune response and additionally increased IFN-c expression.Conclusions/Significance: Immunization with Lu. longipalpis saliva or with a DNA plasmid coding LJM19 salivary protein induced protection in hamsters challenged with L. braziliensis plus Lu. intermedia saliva. These findings point out an important role of immune response against saliva components, suggesting the possibility to develop a vaccine using a single component of Lu. longipalpis saliva to generate protection against different species of Leishmania, even those transmitted by a different vector.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-02-14T12:03:45Z No. of bitstreams: 1 journal.pntd.0001169.pdf: 700787 bytes, checksum: c3ed243c40efaeea57922f38d2948f7d (MD5)Made available in DSpace on 2012-02-14T12:03:45Z (GMT). No. of bitstreams: 1 journal.pntd.0001169.pdf: 700787 bytes, checksum: c3ed243c40efaeea57922f38d2948f7d (MD5) Previous issue date: 2011http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001169reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermediaPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALjournal.pntd.0001169.pdfjournal.pntd.0001169.pdfapplication/pdf700787https://repositorio.ufba.br/bitstream/ri/5417/1/journal.pntd.0001169.pdfc3ed243c40efaeea57922f38d2948f7dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5417/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTjournal.pntd.0001169.pdf.txtjournal.pntd.0001169.pdf.txtExtracted texttext/plain44847https://repositorio.ufba.br/bitstream/ri/5417/3/journal.pntd.0001169.pdf.txt61597a08a680484ba21c9156e0c8a36dMD53ri/54172022-07-05 14:03:44.096oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:44Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
dc.title.alternative.pt_BR.fl_str_mv |
PLoS Neglected Tropical Diseases |
title |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
spellingShingle |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia Tavares, Natália Machado |
title_short |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
title_full |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
title_fullStr |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
title_full_unstemmed |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
title_sort |
Lutzomyia longipalpis Saliva or Salivary Protein LJM19 Protects against Leishmania braziliensis and the Saliva of Its Vector, Lutzomyia intermedia |
author |
Tavares, Natália Machado |
author_facet |
Tavares, Natália Machado Silva, Robson A. Costa, Dirceu Joaquim Pitombo, Maiana A. Fukutani, Kiyoshi Ferreira Miranda, José C. Valenzuela, Jesus G. Barral, Aldina Maria Prado Oliveira, Camila Indiani de Barral-Netto, Manoel Brodskyn, Claudia Ida |
author_role |
author |
author2 |
Silva, Robson A. Costa, Dirceu Joaquim Pitombo, Maiana A. Fukutani, Kiyoshi Ferreira Miranda, José C. Valenzuela, Jesus G. Barral, Aldina Maria Prado Oliveira, Camila Indiani de Barral-Netto, Manoel Brodskyn, Claudia Ida |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tavares, Natália Machado Silva, Robson A. Costa, Dirceu Joaquim Pitombo, Maiana A. Fukutani, Kiyoshi Ferreira Miranda, José C. Valenzuela, Jesus G. Barral, Aldina Maria Prado Oliveira, Camila Indiani de Barral-Netto, Manoel Brodskyn, Claudia Ida Tavares, Natália Machado Silva, Robson A. Costa, Dirceu Joaquim Pitombo, Maiana A. Fukutani, Kiyoshi Ferreira Miranda, José C. Valenzuela, Jesus G. Barral, Aldina Maria Prado Oliveira, Camila Indiani de Barral-Netto, Manoel Brodskyn, Claudia Ida |
description |
p. e1169. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2012-02-14T12:03:45Z |
dc.date.available.fl_str_mv |
2012-02-14T12:03:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://www.repositorio.ufba.br/ri/handle/ri/5417 |
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1935-2727 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 5, n. 5. |
identifier_str_mv |
1935-2727 v. 5, n. 5. |
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http://www.repositorio.ufba.br/ri/handle/ri/5417 |
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eng |
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