B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases

Detalhes bibliográficos
Autor(a) principal: Vieira, M. G. S.
Data de Publicação: 2002
Outros Autores: Oliveira, F., Arruda, Sérgio Marcos, Bittencourt, Achilea Candida Lisboa, Barbosa Júnior, Aryon de Almeida, Barral-Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7458
Resumo: p. 979-983
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spelling Vieira, M. G. S.Oliveira, F.Arruda, Sérgio MarcosBittencourt, Achilea Candida LisboaBarbosa Júnior, Aryon de AlmeidaBarral-Netto, ManoelBarral, Aldina Maria PradoVieira, M. G. S.Oliveira, F.Arruda, Sérgio MarcosBittencourt, Achilea Candida LisboaBarbosa Júnior, Aryon de AlmeidaBarral-Netto, ManoelBarral, Aldina Maria Prado2012-12-12T15:36:20Z2012-12-12T15:36:20Z2002-100074-0276http://www.repositorio.ufba.br/ri/handle/ri/7458v. 97, n. 7p. 979-983Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-y, TNF-a) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-y expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-a and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-y producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-12T15:36:20Z No. of bitstreams: 1 4574.pdf: 57883 bytes, checksum: dcb00a38cbd96d2a01cb584028725a4c (MD5)Made available in DSpace on 2012-12-12T15:36:20Z (GMT). No. of bitstreams: 1 4574.pdf: 57883 bytes, checksum: dcb00a38cbd96d2a01cb584028725a4c (MD5) Previous issue date: 2002-10http://dx.doi.org/10.1590/S0074-02762002000700009reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAleishmaniasisB lymphocytescytokinesCD8+ T cellsIFN-yB-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniasesMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL4574.pdf4574.pdfapplication/pdf57883https://repositorio.ufba.br/bitstream/ri/7458/1/4574.pdfdcb00a38cbd96d2a01cb584028725a4cMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7458/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT4574.pdf.txt4574.pdf.txtExtracted texttext/plain25469https://repositorio.ufba.br/bitstream/ri/7458/3/4574.pdf.txt781fae6bf22be71280ff2fb566f39bc9MD53ri/74582022-07-05 14:03:43.714oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:43Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
spellingShingle B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
Vieira, M. G. S.
leishmaniasis
B lymphocytes
cytokines
CD8+ T cells
IFN-y
title_short B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
title_full B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
title_fullStr B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
title_full_unstemmed B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
title_sort B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
author Vieira, M. G. S.
author_facet Vieira, M. G. S.
Oliveira, F.
Arruda, Sérgio Marcos
Bittencourt, Achilea Candida Lisboa
Barbosa Júnior, Aryon de Almeida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Oliveira, F.
Arruda, Sérgio Marcos
Bittencourt, Achilea Candida Lisboa
Barbosa Júnior, Aryon de Almeida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, M. G. S.
Oliveira, F.
Arruda, Sérgio Marcos
Bittencourt, Achilea Candida Lisboa
Barbosa Júnior, Aryon de Almeida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Vieira, M. G. S.
Oliveira, F.
Arruda, Sérgio Marcos
Bittencourt, Achilea Candida Lisboa
Barbosa Júnior, Aryon de Almeida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.por.fl_str_mv leishmaniasis
B lymphocytes
cytokines
CD8+ T cells
IFN-y
topic leishmaniasis
B lymphocytes
cytokines
CD8+ T cells
IFN-y
description p. 979-983
publishDate 2002
dc.date.issued.fl_str_mv 2002-10
dc.date.accessioned.fl_str_mv 2012-12-12T15:36:20Z
dc.date.available.fl_str_mv 2012-12-12T15:36:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7458
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.number.pt_BR.fl_str_mv v. 97, n. 7
identifier_str_mv 0074-0276
v. 97, n. 7
url http://www.repositorio.ufba.br/ri/handle/ri/7458
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0074-02762002000700009
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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