Central 5-HT4 receptors and drinking behavior

Detalhes bibliográficos
Autor(a) principal: Castro, L.
Data de Publicação: 2000
Outros Autores: Silva, E. de Castro e, Lima, A. K. S., Souza, F. S., Maldonado, I., Macêdo, D. F., Ferreira, M. G., Santamaria, Guillermo Fernandez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7847
Resumo: Texto completo: acesso restrito. p.443–448
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spelling Castro, L.Silva, E. de Castro eLima, A. K. S.Souza, F. S.Maldonado, I.Macêdo, D. F.Ferreira, M. G.Santamaria, Guillermo FernandezCastro, L.Silva, E. de Castro eLima, A. K. S.Souza, F. S.Maldonado, I.Macêdo, D. F.Ferreira, M. G.Santamaria, Guillermo Fernandez2013-01-14T14:06:58Z20000091-3057http://www.repositorio.ufba.br/ri/handle/ri/7847v.66, n.2Texto completo: acesso restrito. p.443–448The aim of the present study was to investigate the effect of acute third ventricle injections of two different 5-HT4 receptor antagonists, GR 113808 and SB 204070, on water intake in different situations. Injections of 80 nmol/rat of both GR 113808 and SB 204070 were unable to modify water intake in normohydrated rats. Pretreatment with GR 113808 (40 and 80 nmol/rat) and SB 204070 (80 and 160 nmol/rat) blunted water intake after third ventricle injections of angiotensin II (9.6 pmol/rat) compared to saline-pretreated controls. Pretreatment with 80 nmol/rat of both antagonists potentiated drinking induced by third ventricle injections of carbachol (11.0 nmol/rat) compared to saline-pretreated control. In all doses employed, none of the compounds was able to modify water intake in dehydrated rats. A separate control test using one-bottle taste aversion paradigm indicated that the reduction in water intake observed in some of the present experiments could not be attributed to a drug-induced malaise. It is suggested that central 5-HT4 receptors exert a dualistic role on the control of water intake potentiating angiotensin II-induced drinking and inhibiting thirst induced by central cholinergic activation.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-14T14:06:58Z No. of bitstreams: 1 Castro.pdf: 158237 bytes, checksum: d70d8e54b95200e9309f175d2a15f000 (MD5)Made available in DSpace on 2013-01-14T14:06:58Z (GMT). No. of bitstreams: 1 Castro.pdf: 158237 bytes, checksum: d70d8e54b95200e9309f175d2a15f000 (MD5) Previous issue date: 2000http://dx.doi.org/10.1016/S0091-3057(00)00226-4reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBA5-HT4 receptorsDrinking behaviorThird ventricle injectionsCentral 5-HT4 receptors and drinking behaviorPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALCastro.pdfCastro.pdfapplication/pdf158237https://repositorio.ufba.br/bitstream/ri/7847/1/Castro.pdfd70d8e54b95200e9309f175d2a15f000MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7847/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTCastro.pdf.txtCastro.pdf.txtExtracted texttext/plain35857https://repositorio.ufba.br/bitstream/ri/7847/3/Castro.pdf.txta47ffe5464a2beb424f58d0b93ec35c4MD53ri/78472022-08-08 13:17:43.916oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:43Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Central 5-HT4 receptors and drinking behavior
dc.title.alternative.pt_BR.fl_str_mv Pharmacology Biochemistry and Behavior
title Central 5-HT4 receptors and drinking behavior
spellingShingle Central 5-HT4 receptors and drinking behavior
Castro, L.
5-HT4 receptors
Drinking behavior
Third ventricle injections
title_short Central 5-HT4 receptors and drinking behavior
title_full Central 5-HT4 receptors and drinking behavior
title_fullStr Central 5-HT4 receptors and drinking behavior
title_full_unstemmed Central 5-HT4 receptors and drinking behavior
title_sort Central 5-HT4 receptors and drinking behavior
author Castro, L.
author_facet Castro, L.
Silva, E. de Castro e
Lima, A. K. S.
Souza, F. S.
Maldonado, I.
Macêdo, D. F.
Ferreira, M. G.
Santamaria, Guillermo Fernandez
author_role author
author2 Silva, E. de Castro e
Lima, A. K. S.
Souza, F. S.
Maldonado, I.
Macêdo, D. F.
Ferreira, M. G.
Santamaria, Guillermo Fernandez
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, L.
Silva, E. de Castro e
Lima, A. K. S.
Souza, F. S.
Maldonado, I.
Macêdo, D. F.
Ferreira, M. G.
Santamaria, Guillermo Fernandez
Castro, L.
Silva, E. de Castro e
Lima, A. K. S.
Souza, F. S.
Maldonado, I.
Macêdo, D. F.
Ferreira, M. G.
Santamaria, Guillermo Fernandez
dc.subject.por.fl_str_mv 5-HT4 receptors
Drinking behavior
Third ventricle injections
topic 5-HT4 receptors
Drinking behavior
Third ventricle injections
description Texto completo: acesso restrito. p.443–448
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2013-01-14T14:06:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7847
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v.66, n.2
identifier_str_mv 0091-3057
v.66, n.2
url http://www.repositorio.ufba.br/ri/handle/ri/7847
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0091-3057(00)00226-4
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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