Epidemiological profile of congenital hypothyroidism at a southern Brazilian state

Detalhes bibliográficos
Autor(a) principal: Rizzotto, Márcia Inês Boff
Data de Publicação: 2023
Outros Autores: Kopacek, Cristiane, Souza, Vandréa Carla de, Ribeiro, Sabliny Carreiro, Kreisner, Edmundo, Vargas, Paula Regla, Mastella, Lívia Silveira, Madi, José Mauro, Castro, Simone Martins de, Garcia, Rosa Maria Rahmi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/264092
Resumo: Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). Subjects and methods: Historical cohort study including all newborns screened for CH by the RSNS-RS from January 2008 until December 2017. Data of all newborns with neonatal TSH (neoTSH; heel prick test) values ≥ 9 mIU/L were collected. According to neoTSH values, the newborns were allocated into two groups: Group 1 (G1), comprising newborns with neoTSH ≥ 9 mIU/L and serum TSH (sTSH) < 10 mIU/L, and Group 2 (G2), comprising those with neoTSH ≥ 9 mIU/L and sTSH ≥ 10 mIU/L. Results: Of 1,043,565 newborns screened, 829 (0.08%) had neoTSH values ≥ 9 mIU/L. Of these, 284 (39.3%) had sTSH values < 10 mIU/L and were allocated to the G1 group, while 439 (60.7%) had sTSH ≥ 10 mIU/L and were allocated to the G2 group, and 106 (12.7%) were considered missing data. The overall incidence of CH was 42.1 per 100,000 newborns screened (95% confidence interval [CI] 38.5- 45.7/100,000) or 1:2377 screened newborns. The sensibility and specificity of neoTSH ≥ 9 mIU/L were 97% and 11%; of neoTSH 12.6 mUI/L, 73% and 85% respectively. Conclusion: In this population, the incidence of permanent and transitory CH was 1:2377 screened newborns. The neoTSH cutoff value adopted during the study period showed excellent sensibility, which matters for a screening test.
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spelling Rizzotto, Márcia Inês BoffKopacek, CristianeSouza, Vandréa Carla deRibeiro, Sabliny CarreiroKreisner, EdmundoVargas, Paula ReglaMastella, Lívia SilveiraMadi, José MauroCastro, Simone Martins deGarcia, Rosa Maria Rahmi2023-08-30T03:59:56Z20232359-4292http://hdl.handle.net/10183/264092001169146Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). Subjects and methods: Historical cohort study including all newborns screened for CH by the RSNS-RS from January 2008 until December 2017. Data of all newborns with neonatal TSH (neoTSH; heel prick test) values ≥ 9 mIU/L were collected. According to neoTSH values, the newborns were allocated into two groups: Group 1 (G1), comprising newborns with neoTSH ≥ 9 mIU/L and serum TSH (sTSH) < 10 mIU/L, and Group 2 (G2), comprising those with neoTSH ≥ 9 mIU/L and sTSH ≥ 10 mIU/L. Results: Of 1,043,565 newborns screened, 829 (0.08%) had neoTSH values ≥ 9 mIU/L. Of these, 284 (39.3%) had sTSH values < 10 mIU/L and were allocated to the G1 group, while 439 (60.7%) had sTSH ≥ 10 mIU/L and were allocated to the G2 group, and 106 (12.7%) were considered missing data. The overall incidence of CH was 42.1 per 100,000 newborns screened (95% confidence interval [CI] 38.5- 45.7/100,000) or 1:2377 screened newborns. The sensibility and specificity of neoTSH ≥ 9 mIU/L were 97% and 11%; of neoTSH 12.6 mUI/L, 73% and 85% respectively. Conclusion: In this population, the incidence of permanent and transitory CH was 1:2377 screened newborns. The neoTSH cutoff value adopted during the study period showed excellent sensibility, which matters for a screening test.application/pdfengArchives of endocrinology and metabolism. São Paulo. Vol. 67, n. 4 (2023), e000606, 9 p.Hipotireoidismo congênitoTriagem neonatalSaúde públicaIncidênciaCongenital hypothyroidismNeonatal screeningPublic healthIncidenceEpidemiological profile of congenital hypothyroidism at a southern Brazilian stateinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001169146.pdf.txt001169146.pdf.txtExtracted Texttext/plain37175http://www.lume.ufrgs.br/bitstream/10183/264092/2/001169146.pdf.txt1f03f899b0378a16fa89eba5c458834bMD52ORIGINAL001169146.pdfTexto completo (inglês)application/pdf165661http://www.lume.ufrgs.br/bitstream/10183/264092/1/001169146.pdf0682fa710ab3789d5d1cd45896852e3bMD5110183/2640922023-08-31 03:34:01.167935oai:www.lume.ufrgs.br:10183/264092Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-31T06:34:01Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
title Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
spellingShingle Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
Rizzotto, Márcia Inês Boff
Hipotireoidismo congênito
Triagem neonatal
Saúde pública
Incidência
Congenital hypothyroidism
Neonatal screening
Public health
Incidence
title_short Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
title_full Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
title_fullStr Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
title_full_unstemmed Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
title_sort Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
author Rizzotto, Márcia Inês Boff
author_facet Rizzotto, Márcia Inês Boff
Kopacek, Cristiane
Souza, Vandréa Carla de
Ribeiro, Sabliny Carreiro
Kreisner, Edmundo
Vargas, Paula Regla
Mastella, Lívia Silveira
Madi, José Mauro
Castro, Simone Martins de
Garcia, Rosa Maria Rahmi
author_role author
author2 Kopacek, Cristiane
Souza, Vandréa Carla de
Ribeiro, Sabliny Carreiro
Kreisner, Edmundo
Vargas, Paula Regla
Mastella, Lívia Silveira
Madi, José Mauro
Castro, Simone Martins de
Garcia, Rosa Maria Rahmi
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rizzotto, Márcia Inês Boff
Kopacek, Cristiane
Souza, Vandréa Carla de
Ribeiro, Sabliny Carreiro
Kreisner, Edmundo
Vargas, Paula Regla
Mastella, Lívia Silveira
Madi, José Mauro
Castro, Simone Martins de
Garcia, Rosa Maria Rahmi
dc.subject.por.fl_str_mv Hipotireoidismo congênito
Triagem neonatal
Saúde pública
Incidência
topic Hipotireoidismo congênito
Triagem neonatal
Saúde pública
Incidência
Congenital hypothyroidism
Neonatal screening
Public health
Incidence
dc.subject.eng.fl_str_mv Congenital hypothyroidism
Neonatal screening
Public health
Incidence
description Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). Subjects and methods: Historical cohort study including all newborns screened for CH by the RSNS-RS from January 2008 until December 2017. Data of all newborns with neonatal TSH (neoTSH; heel prick test) values ≥ 9 mIU/L were collected. According to neoTSH values, the newborns were allocated into two groups: Group 1 (G1), comprising newborns with neoTSH ≥ 9 mIU/L and serum TSH (sTSH) < 10 mIU/L, and Group 2 (G2), comprising those with neoTSH ≥ 9 mIU/L and sTSH ≥ 10 mIU/L. Results: Of 1,043,565 newborns screened, 829 (0.08%) had neoTSH values ≥ 9 mIU/L. Of these, 284 (39.3%) had sTSH values < 10 mIU/L and were allocated to the G1 group, while 439 (60.7%) had sTSH ≥ 10 mIU/L and were allocated to the G2 group, and 106 (12.7%) were considered missing data. The overall incidence of CH was 42.1 per 100,000 newborns screened (95% confidence interval [CI] 38.5- 45.7/100,000) or 1:2377 screened newborns. The sensibility and specificity of neoTSH ≥ 9 mIU/L were 97% and 11%; of neoTSH 12.6 mUI/L, 73% and 85% respectively. Conclusion: In this population, the incidence of permanent and transitory CH was 1:2377 screened newborns. The neoTSH cutoff value adopted during the study period showed excellent sensibility, which matters for a screening test.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-30T03:59:56Z
dc.date.issued.fl_str_mv 2023
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dc.identifier.issn.pt_BR.fl_str_mv 2359-4292
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Archives of endocrinology and metabolism. São Paulo. Vol. 67, n. 4 (2023), e000606, 9 p.
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