Epidemiological profile of congenital hypothyroidism at a southern Brazilian state
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/264092 |
Resumo: | Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). Subjects and methods: Historical cohort study including all newborns screened for CH by the RSNS-RS from January 2008 until December 2017. Data of all newborns with neonatal TSH (neoTSH; heel prick test) values ≥ 9 mIU/L were collected. According to neoTSH values, the newborns were allocated into two groups: Group 1 (G1), comprising newborns with neoTSH ≥ 9 mIU/L and serum TSH (sTSH) < 10 mIU/L, and Group 2 (G2), comprising those with neoTSH ≥ 9 mIU/L and sTSH ≥ 10 mIU/L. Results: Of 1,043,565 newborns screened, 829 (0.08%) had neoTSH values ≥ 9 mIU/L. Of these, 284 (39.3%) had sTSH values < 10 mIU/L and were allocated to the G1 group, while 439 (60.7%) had sTSH ≥ 10 mIU/L and were allocated to the G2 group, and 106 (12.7%) were considered missing data. The overall incidence of CH was 42.1 per 100,000 newborns screened (95% confidence interval [CI] 38.5- 45.7/100,000) or 1:2377 screened newborns. The sensibility and specificity of neoTSH ≥ 9 mIU/L were 97% and 11%; of neoTSH 12.6 mUI/L, 73% and 85% respectively. Conclusion: In this population, the incidence of permanent and transitory CH was 1:2377 screened newborns. The neoTSH cutoff value adopted during the study period showed excellent sensibility, which matters for a screening test. |
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Rizzotto, Márcia Inês BoffKopacek, CristianeSouza, Vandréa Carla deRibeiro, Sabliny CarreiroKreisner, EdmundoVargas, Paula ReglaMastella, Lívia SilveiraMadi, José MauroCastro, Simone Martins deGarcia, Rosa Maria Rahmi2023-08-30T03:59:56Z20232359-4292http://hdl.handle.net/10183/264092001169146Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). Subjects and methods: Historical cohort study including all newborns screened for CH by the RSNS-RS from January 2008 until December 2017. Data of all newborns with neonatal TSH (neoTSH; heel prick test) values ≥ 9 mIU/L were collected. According to neoTSH values, the newborns were allocated into two groups: Group 1 (G1), comprising newborns with neoTSH ≥ 9 mIU/L and serum TSH (sTSH) < 10 mIU/L, and Group 2 (G2), comprising those with neoTSH ≥ 9 mIU/L and sTSH ≥ 10 mIU/L. Results: Of 1,043,565 newborns screened, 829 (0.08%) had neoTSH values ≥ 9 mIU/L. Of these, 284 (39.3%) had sTSH values < 10 mIU/L and were allocated to the G1 group, while 439 (60.7%) had sTSH ≥ 10 mIU/L and were allocated to the G2 group, and 106 (12.7%) were considered missing data. The overall incidence of CH was 42.1 per 100,000 newborns screened (95% confidence interval [CI] 38.5- 45.7/100,000) or 1:2377 screened newborns. The sensibility and specificity of neoTSH ≥ 9 mIU/L were 97% and 11%; of neoTSH 12.6 mUI/L, 73% and 85% respectively. Conclusion: In this population, the incidence of permanent and transitory CH was 1:2377 screened newborns. The neoTSH cutoff value adopted during the study period showed excellent sensibility, which matters for a screening test.application/pdfengArchives of endocrinology and metabolism. São Paulo. Vol. 67, n. 4 (2023), e000606, 9 p.Hipotireoidismo congênitoTriagem neonatalSaúde públicaIncidênciaCongenital hypothyroidismNeonatal screeningPublic healthIncidenceEpidemiological profile of congenital hypothyroidism at a southern Brazilian stateinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001169146.pdf.txt001169146.pdf.txtExtracted Texttext/plain37175http://www.lume.ufrgs.br/bitstream/10183/264092/2/001169146.pdf.txt1f03f899b0378a16fa89eba5c458834bMD52ORIGINAL001169146.pdfTexto completo (inglês)application/pdf165661http://www.lume.ufrgs.br/bitstream/10183/264092/1/001169146.pdf0682fa710ab3789d5d1cd45896852e3bMD5110183/2640922023-08-31 03:34:01.167935oai:www.lume.ufrgs.br:10183/264092Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-31T06:34:01Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
title |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
spellingShingle |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state Rizzotto, Márcia Inês Boff Hipotireoidismo congênito Triagem neonatal Saúde pública Incidência Congenital hypothyroidism Neonatal screening Public health Incidence |
title_short |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
title_full |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
title_fullStr |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
title_full_unstemmed |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
title_sort |
Epidemiological profile of congenital hypothyroidism at a southern Brazilian state |
author |
Rizzotto, Márcia Inês Boff |
author_facet |
Rizzotto, Márcia Inês Boff Kopacek, Cristiane Souza, Vandréa Carla de Ribeiro, Sabliny Carreiro Kreisner, Edmundo Vargas, Paula Regla Mastella, Lívia Silveira Madi, José Mauro Castro, Simone Martins de Garcia, Rosa Maria Rahmi |
author_role |
author |
author2 |
Kopacek, Cristiane Souza, Vandréa Carla de Ribeiro, Sabliny Carreiro Kreisner, Edmundo Vargas, Paula Regla Mastella, Lívia Silveira Madi, José Mauro Castro, Simone Martins de Garcia, Rosa Maria Rahmi |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rizzotto, Márcia Inês Boff Kopacek, Cristiane Souza, Vandréa Carla de Ribeiro, Sabliny Carreiro Kreisner, Edmundo Vargas, Paula Regla Mastella, Lívia Silveira Madi, José Mauro Castro, Simone Martins de Garcia, Rosa Maria Rahmi |
dc.subject.por.fl_str_mv |
Hipotireoidismo congênito Triagem neonatal Saúde pública Incidência |
topic |
Hipotireoidismo congênito Triagem neonatal Saúde pública Incidência Congenital hypothyroidism Neonatal screening Public health Incidence |
dc.subject.eng.fl_str_mv |
Congenital hypothyroidism Neonatal screening Public health Incidence |
description |
Objective: To determine the incidence of congenital hypothyroidism (CH) over a 10-year period at the Reference Service in Neonatal Screening of the state of Rio Grande do Sul (RSNS-RS). Subjects and methods: Historical cohort study including all newborns screened for CH by the RSNS-RS from January 2008 until December 2017. Data of all newborns with neonatal TSH (neoTSH; heel prick test) values ≥ 9 mIU/L were collected. According to neoTSH values, the newborns were allocated into two groups: Group 1 (G1), comprising newborns with neoTSH ≥ 9 mIU/L and serum TSH (sTSH) < 10 mIU/L, and Group 2 (G2), comprising those with neoTSH ≥ 9 mIU/L and sTSH ≥ 10 mIU/L. Results: Of 1,043,565 newborns screened, 829 (0.08%) had neoTSH values ≥ 9 mIU/L. Of these, 284 (39.3%) had sTSH values < 10 mIU/L and were allocated to the G1 group, while 439 (60.7%) had sTSH ≥ 10 mIU/L and were allocated to the G2 group, and 106 (12.7%) were considered missing data. The overall incidence of CH was 42.1 per 100,000 newborns screened (95% confidence interval [CI] 38.5- 45.7/100,000) or 1:2377 screened newborns. The sensibility and specificity of neoTSH ≥ 9 mIU/L were 97% and 11%; of neoTSH 12.6 mUI/L, 73% and 85% respectively. Conclusion: In this population, the incidence of permanent and transitory CH was 1:2377 screened newborns. The neoTSH cutoff value adopted during the study period showed excellent sensibility, which matters for a screening test. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-08-30T03:59:56Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/264092 |
dc.identifier.issn.pt_BR.fl_str_mv |
2359-4292 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001169146 |
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2359-4292 001169146 |
url |
http://hdl.handle.net/10183/264092 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Archives of endocrinology and metabolism. São Paulo. Vol. 67, n. 4 (2023), e000606, 9 p. |
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