Avaliação da eficácia terapêutica da administração da lactase em pacientes com intolerância à lactose através de teste respiratório

• Autor(a) principal: Santos, Sérgio Ricardo Alves dos
• Data de Publicação: 2017
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: http://ri.ufs.br/jspui/handle/riufs/7443
• topic: Medicina; Saúde; Intolerância a lactose; Diagnóstico; Medicine; Lactose intolerance; Diagnosis; CIENCIAS DA SAUDE::MEDICINA

In most people after the infancy stage there is a reduction of the activity of lactase proceeding in an insufficient absortion of lactose. Lactose intolerance (IL) is a potentially pathological condition in the world population, with a prevalence of over 20% in the Caucasian population in the USA and Europe and above 75% and 90% in Africans and Asians, respectively. This study proposes evaluate the clinical improvement after the use of the enzyme Aspergillus oryzae, in the doses of 10000 and 20000 FCCALU, through the application of a questionnaire based on the Visual Analogue Scale (VAS). It is also the object of this study to evaluate the clinical improvement after the use of the enzyme Aspergillus oryzae, in doses of 10,000 and 20,000 FCU ALU, through the application of a Visual Analogue Scale (VAS) questionnaire which describes the symptoms presented during and up to 8 hours after the examination. METHODS This is an uncontrolled and non-randomized clinical trial carried out in a university hospital outpatient clinic and in a private clinic it was performed in patients diagnosed with lactose intolerance, by the Exhaled Hydrogen Respiratory Test with age range between 18 and 65 years. The basal H2 concentration was determined by requiring the patient to expire for 15 seconds on the Daynamed Easy appliance, after a ingestion of 25g of lactose. Patients with positive test received 10,0000 FCC ALU from the enzyme and every thirty minutes for three hours samples of expired air were collected. In the second stage of the study the patients with positive test were submitted to a new test adding 10,000 FCC ALU of lactase to the standard load of lactose (25g). Patients who did not respond satisfactorily were retested and received 20,000 FCCALU from the same enzyme. The evaluation of the improvement of the symptoms to the use of the enzyme was made through the answers to the questionnaire based on the Visual Analogue Scale (VAS) the intensity of symptoms ranges from 0 to 10. The H2 concentration curves were compared with previous examination and each patient was considered the control of itself. RESULTS The clinical characteristics of the patients characteristics were found 54.16% female, BMI (mean of standard deviation) = 24.6, Caucasian 37.5%, black 4.76% and brown 54.16%. Regarding the degree of severity of lactose intolerance, it was shown that 16.67% presented mild degree, 29.22% presented moderate degree and 50% presented severe grade. CONCLUSION In this study, the enzyme treatment obtained from aspergillo was evaluated in patients with clinical diagnosis of lactose intolerance by the Exhaled Hydrogen Respiratory Test. This treatment was effective in improving gastrointestinal symptoms and was demonstrated by the reduction of H2 excretion, with no side effects, and results superior to the beta-galactosidase enzyme treatment.