Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1746-160X-7-7 http://hdl.handle.net/11449/16040 |
Resumo: | Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition characterized by the presence of exposed bone in the maxillofacial region. Its pathogenesis is still undetermined, but may be associated with risk factors such as rheumatoid arthritis (RA). The aim of this paper is to report two unpublished cases of BRONJ in patients with RA and to conduct a literature review of similar clinical cases with a view to describe the main issues concerning these patients, including demographic characteristics and therapeutic approaches applied.Methods: Two case reports of BRONJ involving RA patients were discussedResults: Both patients were aging female taking alendronate for more than 3 years. Lesions were detected in stage II in posterior mandible with no clear trigger agent. The treatment applied consisted of antibiotics, oral rinses with chlorhexidine, drug discontinuation and surgical procedures. Complete healing of the lesions was achieved.Conclusions: This paper brings to light the necessity for rheumatologists to be aware of the potential risk to their patients of developing BRONJ and to work together with dentists for the prevention and early detection of the lesions. Although some features seem to link RA with oral BRONJ and act as synergistic effects, more studies should be developed to support the scientific bases for this hypothesis. |
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spelling |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reportsBackground: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition characterized by the presence of exposed bone in the maxillofacial region. Its pathogenesis is still undetermined, but may be associated with risk factors such as rheumatoid arthritis (RA). The aim of this paper is to report two unpublished cases of BRONJ in patients with RA and to conduct a literature review of similar clinical cases with a view to describe the main issues concerning these patients, including demographic characteristics and therapeutic approaches applied.Methods: Two case reports of BRONJ involving RA patients were discussedResults: Both patients were aging female taking alendronate for more than 3 years. Lesions were detected in stage II in posterior mandible with no clear trigger agent. The treatment applied consisted of antibiotics, oral rinses with chlorhexidine, drug discontinuation and surgical procedures. Complete healing of the lesions was achieved.Conclusions: This paper brings to light the necessity for rheumatologists to be aware of the potential risk to their patients of developing BRONJ and to work together with dentists for the prevention and early detection of the lesions. Although some features seem to link RA with oral BRONJ and act as synergistic effects, more studies should be developed to support the scientific bases for this hypothesis.Univ Estadual Paulista, UNESP, Sch Dent, Dept Diag & Surg,Div Periodontol, BR-14801903 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Sch Dent, Dept Physiol & Pathol,Div Pathol, BR-14801903 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Sch Dent, Dept Diag & Surg,Div Periodontol, BR-14801903 Araraquara, SP, BrazilUniv Estadual Paulista, UNESP, Sch Dent, Dept Physiol & Pathol,Div Pathol, BR-14801903 Araraquara, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Conte-Neto, Nicolau [UNESP]Bastos, Alliny S. [UNESP]Spolidório, Luis Carlos [UNESP]Marcantonio, Rosemary Adriana Chierici [UNESP]Marcantonio, Elcio [UNESP]2014-05-20T13:45:34Z2014-05-20T13:45:34Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1746-160X-7-7Head & Face Medicine. London: Biomed Central Ltd., v. 7, p. 7, 2011.1746-160Xhttp://hdl.handle.net/11449/1604010.1186/1746-160X-7-7WOS:000208595400007WOS000208595400007.pdf26409292918084153534044399884035Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHead & Face Medicine1.606info:eu-repo/semantics/openAccess2023-10-29T06:09:47Zoai:repositorio.unesp.br:11449/16040Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:22:40.034575Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
title |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
spellingShingle |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports Conte-Neto, Nicolau [UNESP] |
title_short |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
title_full |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
title_fullStr |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
title_full_unstemmed |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
title_sort |
Oral bisphosphonate-related osteonecrosis of the jaws in rheumatoid arthritis patients: a critical discussion and two case reports |
author |
Conte-Neto, Nicolau [UNESP] |
author_facet |
Conte-Neto, Nicolau [UNESP] Bastos, Alliny S. [UNESP] Spolidório, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana Chierici [UNESP] Marcantonio, Elcio [UNESP] |
author_role |
author |
author2 |
Bastos, Alliny S. [UNESP] Spolidório, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana Chierici [UNESP] Marcantonio, Elcio [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Conte-Neto, Nicolau [UNESP] Bastos, Alliny S. [UNESP] Spolidório, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana Chierici [UNESP] Marcantonio, Elcio [UNESP] |
description |
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition characterized by the presence of exposed bone in the maxillofacial region. Its pathogenesis is still undetermined, but may be associated with risk factors such as rheumatoid arthritis (RA). The aim of this paper is to report two unpublished cases of BRONJ in patients with RA and to conduct a literature review of similar clinical cases with a view to describe the main issues concerning these patients, including demographic characteristics and therapeutic approaches applied.Methods: Two case reports of BRONJ involving RA patients were discussedResults: Both patients were aging female taking alendronate for more than 3 years. Lesions were detected in stage II in posterior mandible with no clear trigger agent. The treatment applied consisted of antibiotics, oral rinses with chlorhexidine, drug discontinuation and surgical procedures. Complete healing of the lesions was achieved.Conclusions: This paper brings to light the necessity for rheumatologists to be aware of the potential risk to their patients of developing BRONJ and to work together with dentists for the prevention and early detection of the lesions. Although some features seem to link RA with oral BRONJ and act as synergistic effects, more studies should be developed to support the scientific bases for this hypothesis. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2014-05-20T13:45:34Z 2014-05-20T13:45:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1746-160X-7-7 Head & Face Medicine. London: Biomed Central Ltd., v. 7, p. 7, 2011. 1746-160X http://hdl.handle.net/11449/16040 10.1186/1746-160X-7-7 WOS:000208595400007 WOS000208595400007.pdf 2640929291808415 3534044399884035 |
url |
http://dx.doi.org/10.1186/1746-160X-7-7 http://hdl.handle.net/11449/16040 |
identifier_str_mv |
Head & Face Medicine. London: Biomed Central Ltd., v. 7, p. 7, 2011. 1746-160X 10.1186/1746-160X-7-7 WOS:000208595400007 WOS000208595400007.pdf 2640929291808415 3534044399884035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Head & Face Medicine 1.606 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128640356974592 |