Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1590/0037-8682-0612-2022 http://hdl.handle.net/11449/247109 |
Resumo: | Background: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. Results: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. Conclusions: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented. |
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Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in BrazilGenetic DiversityGeographic Information SystemLeprosyMycobacterium lepraeTransmissionBackground: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. Results: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. Conclusions: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto Lauro de Souza Lima, SPUniversidade Estadual Paulista Faculdade de Medicina, SPFundação Oswaldo Cruz Laboratório de Biologia Molecular Aplicada a Micobactérias, RJUniversidade Estadual Paulista Faculdade de Medicina, SPInstituto Lauro de Souza LimaUniversidade Estadual Paulista (UNESP)Laboratório de Biologia Molecular Aplicada a MicobactériasFinardi, Amanda Juliane [UNESP]de Oliveira, Nathan Guilherme [UNESP]de Moraes, Eloise Brasil [UNESP]Batista, Lavínia Cássia Ferreira [UNESP]Bortolomai, Bruna Eduarda [UNESP]Suffys, Philip NoelBaptista, Ida Maria Foschiani Dias [UNESP]2023-07-29T13:06:34Z2023-07-29T13:06:34Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0037-8682-0612-2022Revista da Sociedade Brasileira de Medicina Tropical, v. 56.0037-8682http://hdl.handle.net/11449/24710910.1590/0037-8682-0612-20222-s2.0-85151573459Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Sociedade Brasileira de Medicina Tropicalinfo:eu-repo/semantics/openAccess2023-07-29T13:06:34Zoai:repositorio.unesp.br:11449/247109Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T19:27:00.084948Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| title |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| spellingShingle |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil Finardi, Amanda Juliane [UNESP] Genetic Diversity Geographic Information System Leprosy Mycobacterium leprae Transmission |
| title_short |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| title_full |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| title_fullStr |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| title_full_unstemmed |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| title_sort |
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil |
| author |
Finardi, Amanda Juliane [UNESP] |
| author_facet |
Finardi, Amanda Juliane [UNESP] de Oliveira, Nathan Guilherme [UNESP] de Moraes, Eloise Brasil [UNESP] Batista, Lavínia Cássia Ferreira [UNESP] Bortolomai, Bruna Eduarda [UNESP] Suffys, Philip Noel Baptista, Ida Maria Foschiani Dias [UNESP] |
| author_role |
author |
| author2 |
de Oliveira, Nathan Guilherme [UNESP] de Moraes, Eloise Brasil [UNESP] Batista, Lavínia Cássia Ferreira [UNESP] Bortolomai, Bruna Eduarda [UNESP] Suffys, Philip Noel Baptista, Ida Maria Foschiani Dias [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto Lauro de Souza Lima Universidade Estadual Paulista (UNESP) Laboratório de Biologia Molecular Aplicada a Micobactérias |
| dc.contributor.author.fl_str_mv |
Finardi, Amanda Juliane [UNESP] de Oliveira, Nathan Guilherme [UNESP] de Moraes, Eloise Brasil [UNESP] Batista, Lavínia Cássia Ferreira [UNESP] Bortolomai, Bruna Eduarda [UNESP] Suffys, Philip Noel Baptista, Ida Maria Foschiani Dias [UNESP] |
| dc.subject.por.fl_str_mv |
Genetic Diversity Geographic Information System Leprosy Mycobacterium leprae Transmission |
| topic |
Genetic Diversity Geographic Information System Leprosy Mycobacterium leprae Transmission |
| description |
Background: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. Results: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. Conclusions: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07-29T13:06:34Z 2023-07-29T13:06:34Z 2023-01-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0612-2022 Revista da Sociedade Brasileira de Medicina Tropical, v. 56. 0037-8682 http://hdl.handle.net/11449/247109 10.1590/0037-8682-0612-2022 2-s2.0-85151573459 |
| url |
http://dx.doi.org/10.1590/0037-8682-0612-2022 http://hdl.handle.net/11449/247109 |
| identifier_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical, v. 56. 0037-8682 10.1590/0037-8682-0612-2022 2-s2.0-85151573459 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Revista da Sociedade Brasileira de Medicina Tropical |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1803045618366545920 |