Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010 |
Resumo: | Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a reliable parameter for considering the patient as cured. |
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Brazilian Journal of Infectious Diseases |
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Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasisVisceral leishmaniasisinterleukininterferonVisceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a reliable parameter for considering the patient as cured.Brazilian Society of Infectious Diseases2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010Brazilian Journal of Infectious Diseases v.13 n.1 2009reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702009000100010info:eu-repo/semantics/openAccessKhoshdel,A.Alborzi,A.Rosouli,M.Taheri,E.Kiany,S.Javadian,M.H.eng2009-06-30T00:00:00Zoai:scielo:S1413-86702009000100010Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2009-06-30T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
title |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
spellingShingle |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis Khoshdel,A. Visceral leishmaniasis interleukin interferon |
title_short |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
title_full |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
title_fullStr |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
title_full_unstemmed |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
title_sort |
Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis |
author |
Khoshdel,A. |
author_facet |
Khoshdel,A. Alborzi,A. Rosouli,M. Taheri,E. Kiany,S. Javadian,M.H. |
author_role |
author |
author2 |
Alborzi,A. Rosouli,M. Taheri,E. Kiany,S. Javadian,M.H. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Khoshdel,A. Alborzi,A. Rosouli,M. Taheri,E. Kiany,S. Javadian,M.H. |
dc.subject.por.fl_str_mv |
Visceral leishmaniasis interleukin interferon |
topic |
Visceral leishmaniasis interleukin interferon |
description |
Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a reliable parameter for considering the patient as cured. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702009000100010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.13 n.1 2009 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209240691507200 |