Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Khoshdel,A.
Data de Publicação: 2009
Outros Autores: Alborzi,A., Rosouli,M., Taheri,E., Kiany,S., Javadian,M.H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010
Resumo: Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a reliable parameter for considering the patient as cured.
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spelling Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasisVisceral leishmaniasisinterleukininterferonVisceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a reliable parameter for considering the patient as cured.Brazilian Society of Infectious Diseases2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010Brazilian Journal of Infectious Diseases v.13 n.1 2009reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702009000100010info:eu-repo/semantics/openAccessKhoshdel,A.Alborzi,A.Rosouli,M.Taheri,E.Kiany,S.Javadian,M.H.eng2009-06-30T00:00:00Zoai:scielo:S1413-86702009000100010Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2009-06-30T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
title Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
spellingShingle Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
Khoshdel,A.
Visceral leishmaniasis
interleukin
interferon
title_short Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
title_full Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
title_fullStr Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
title_full_unstemmed Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
title_sort Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
author Khoshdel,A.
author_facet Khoshdel,A.
Alborzi,A.
Rosouli,M.
Taheri,E.
Kiany,S.
Javadian,M.H.
author_role author
author2 Alborzi,A.
Rosouli,M.
Taheri,E.
Kiany,S.
Javadian,M.H.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Khoshdel,A.
Alborzi,A.
Rosouli,M.
Taheri,E.
Kiany,S.
Javadian,M.H.
dc.subject.por.fl_str_mv Visceral leishmaniasis
interleukin
interferon
topic Visceral leishmaniasis
interleukin
interferon
description Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a reliable parameter for considering the patient as cured.
publishDate 2009
dc.date.none.fl_str_mv 2009-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702009000100010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.13 n.1 2009
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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