Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?

Detalhes bibliográficos
Autor(a) principal: Golinelli, Giulia
Data de Publicação: 2020
Outros Autores: Mastrolia, Ilenia, Aramini, Beatrice, Masciale, Valentina, Pinelli, Massimo, Pacchioni, Lucrezia, Casari, Giulia, Dall’Ora, Massimiliano, Soares, Milena Botelho Pereira, Damasceno, Patrícia Kauanna Fonseca, Silva, Daniela Nascimento, Dominici, Massimo, Grisendi, Giulia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45977
Resumo: Associazione Italiana Ricerca Cancro (AIRC) IG2012 Grant #12755; AIRC IG 2015 Grant 17326 Ministero Italiano Istruzione Università e Ricerca PRIN 2008WECX78, Project “Dipartimenti Eccellenti MIUR 2017” and the Associazione ASEOP.
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spelling Golinelli, GiuliaMastrolia, IleniaAramini, BeatriceMasciale, ValentinaPinelli, MassimoPacchioni, LucreziaCasari, GiuliaDall’Ora, MassimilianoSoares, Milena Botelho PereiraDamasceno, Patrícia Kauanna FonsecaSilva, Daniela NascimentoDominici, MassimoGrisendi, Giulia2021-02-06T14:06:43Z2021-02-06T14:06:43Z2020GOLINELLI, Giulia et al. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Frontiers in Pharmacology, v. 11, p. 1-14, 2020.1663-9812https://www.arca.fiocruz.br/handle/icict/4597710.3389/fphar.2020.529921Associazione Italiana Ricerca Cancro (AIRC) IG2012 Grant #12755; AIRC IG 2015 Grant 17326 Ministero Italiano Istruzione Università e Ricerca PRIN 2008WECX78, Project “Dipartimenti Eccellenti MIUR 2017” and the Associazione ASEOP.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Thoracic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Thoracic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Plastic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Department of Medical and Surgical Sciences for Children & Adults. Division of Plastic Surgery. Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Health Institute of Technology. Salvador, BA, Brasil.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy / Rigenerand srl,.Modena, Italy.University-Hospital of Modena and Reggio Emilia. Laboratory of Cellular Therapy. Department of Medical and Surgical Sciences for Children & Adults. Division of Oncology, Modena, Italy / Rigenerand srl,.Modena, Italy.Since mesenchymal stromal/stem cells (MSCs) were discovered, researchers have been drawn to study their peculiar biological features, including their immune privileged status and their capacity to selectively migrate into inflammatory areas, including tumors. These properties make MSCs promising cellular vehicles for the delivery of therapeutic molecules in the clinical setting. In recent decades, the engineering of MSCs into biological vehicles carrying anticancer compounds has been achieved in different ways, including the loading of MSCs with chemotherapeutics or drug functionalized nanoparticles (NPs), genetic modifications to force the production of anticancer proteins, and the use of oncolytic viruses. Recently, it has been demonstrated that wild-type and engineered MSCs can release extracellular vesicles (EVs) that contain therapeutic agents. Despite the enthusiasm for MSCs as cyto-pharmaceutical agents, many challenges, including controlling the fate of MSCs after administration, must still be considered. Preclinical results demonstrated that MSCs accumulate in lung, liver, and spleen, which could prevent their engraftment into tumor sites. For this reason, physical, physiological, and biological methods have been implemented to increase MSC concentration in the target tumors. Currently, there are more than 900 registered clinical trials using MSCs. Only a small fraction of these are investigating MSC-based therapies for cancer, but the number of these clinical trials is expected to increase as technology and our understanding of MSCs improve. This review will summarize MSC-based antitumor therapies to generate an increasing awareness of their potential and limits to accelerate their clinical translation.engFrontiers Research FoundationCélulas-Tronco MesenquimaisCâncerCitocina TWEAKTerapia genéticaTerapia celularMesenchymal stromal/stem cellCancerTumor necrosis factor-related apoptosis-inducing ligand,Gene therapyCell therapyArming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45977/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdfGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdfapplication/pdf2111873https://www.arca.fiocruz.br/bitstream/icict/45977/2/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdfad4a20e497d07f945496b7debdd2773cMD52TEXTGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdf.txtGOLINELLI et al Arming Mesenchymal...-2020 v.11 pg. 1-14.pdf.txtExtracted texttext/plain90871https://www.arca.fiocruz.br/bitstream/icict/45977/3/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdf.txtb56605eaa862f165c667e7a1103b6ee5MD53icict/459772023-03-15 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dc.title.pt_BR.fl_str_mv Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
title Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
spellingShingle Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
Golinelli, Giulia
Células-Tronco Mesenquimais
Câncer
Citocina TWEAK
Terapia genética
Terapia celular
Mesenchymal stromal/stem cell
Cancer
Tumor necrosis factor-related apoptosis-inducing ligand,
Gene therapy
Cell therapy
title_short Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
title_full Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
title_fullStr Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
title_full_unstemmed Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
title_sort Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come?
author Golinelli, Giulia
author_facet Golinelli, Giulia
Mastrolia, Ilenia
Aramini, Beatrice
Masciale, Valentina
Pinelli, Massimo
Pacchioni, Lucrezia
Casari, Giulia
Dall’Ora, Massimiliano
Soares, Milena Botelho Pereira
Damasceno, Patrícia Kauanna Fonseca
Silva, Daniela Nascimento
Dominici, Massimo
Grisendi, Giulia
author_role author
author2 Mastrolia, Ilenia
Aramini, Beatrice
Masciale, Valentina
Pinelli, Massimo
Pacchioni, Lucrezia
Casari, Giulia
Dall’Ora, Massimiliano
Soares, Milena Botelho Pereira
Damasceno, Patrícia Kauanna Fonseca
Silva, Daniela Nascimento
Dominici, Massimo
Grisendi, Giulia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Golinelli, Giulia
Mastrolia, Ilenia
Aramini, Beatrice
Masciale, Valentina
Pinelli, Massimo
Pacchioni, Lucrezia
Casari, Giulia
Dall’Ora, Massimiliano
Soares, Milena Botelho Pereira
Damasceno, Patrícia Kauanna Fonseca
Silva, Daniela Nascimento
Dominici, Massimo
Grisendi, Giulia
dc.subject.other.pt_BR.fl_str_mv Células-Tronco Mesenquimais
Câncer
Citocina TWEAK
Terapia genética
Terapia celular
topic Células-Tronco Mesenquimais
Câncer
Citocina TWEAK
Terapia genética
Terapia celular
Mesenchymal stromal/stem cell
Cancer
Tumor necrosis factor-related apoptosis-inducing ligand,
Gene therapy
Cell therapy
dc.subject.en.pt_BR.fl_str_mv Mesenchymal stromal/stem cell
Cancer
Tumor necrosis factor-related apoptosis-inducing ligand,
Gene therapy
Cell therapy
description Associazione Italiana Ricerca Cancro (AIRC) IG2012 Grant #12755; AIRC IG 2015 Grant 17326 Ministero Italiano Istruzione Università e Ricerca PRIN 2008WECX78, Project “Dipartimenti Eccellenti MIUR 2017” and the Associazione ASEOP.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-02-06T14:06:43Z
dc.date.available.fl_str_mv 2021-02-06T14:06:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOLINELLI, Giulia et al. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Frontiers in Pharmacology, v. 11, p. 1-14, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45977
dc.identifier.issn.pt_BR.fl_str_mv 1663-9812
dc.identifier.doi.none.fl_str_mv 10.3389/fphar.2020.529921
identifier_str_mv GOLINELLI, Giulia et al. Arming Mesenchymal Stromal/Stem Cells Against Cancer: Has the Time Come? Frontiers in Pharmacology, v. 11, p. 1-14, 2020.
1663-9812
10.3389/fphar.2020.529921
url https://www.arca.fiocruz.br/handle/icict/45977
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/45977/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/45977/2/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdf
https://www.arca.fiocruz.br/bitstream/icict/45977/3/GOLINELLI%20et%20al%20Arming%20Mesenchymal...-2020%20v.11%20%20pg.%201-14.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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