Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/150493 |
Resumo: | projects LA/P/0037/2020. P.S. acknowledges the individual contract CEECIND. 03189.2020. Publisher Copyright: © 2022 by the authors. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled DeliveryOptimization of Hydrogel Composition based on Rheological Behavioralginategellan gumhydrogelsPluronicrheologythermoresponsiveCondensed Matter PhysicsMechanical EngineeringFluid Flow and Transfer Processesprojects LA/P/0037/2020. P.S. acknowledges the individual contract CEECIND. 03189.2020. Publisher Copyright: © 2022 by the authors.Due to the high complexity of some treatments, there is a need to develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages of treatment. In this study, a thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within a thermoresponsive Pluronic hydrogel composed of a mixture of Pluronic F127 and F68. The increase in F68 ratio and decrease in F127 lead to higher transition temperatures. The addition of the GG:Alg microparticles decreased the transition temperatures with a linear tendency. In Pluronic aqueous solutions (20 wt.%), the F127:F68 ratios of 16:4 and 17:3 (wt.%:wt.%) and the addition of microparticles (up to 15 wt.%) maintained the sol–gel transition temperatures within a suitable range (between 25 °C and 37 °C). Microparticles did not hinder the injectability of the system in the sol phase. Methylene blue was used as a model drug to evaluate the release mechanisms from microparticles, hydrogel, and composite system. The hydrogel delayed the release of methylene blue from the microparticles. The hydrogel loaded with methylene blue released at a faster rate than the microparticles within the hydrogel, thus demonstrating a dual-release profile.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNCarrêlo, HenriqueEscoval, André R.Soares, Paula I. P.Borges, João P.Cidade, Maria Teresa2023-03-13T22:27:42Z2022-12-062022-12-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/150493engCarrêlo, H., Escoval, A. R., Soares, P. I. P., Borges, J. P., & Cidade, M. T. (2022). Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery: Optimization of Hydrogel Composition based on Rheological Behavior. FLUIDS, 7(12), [375]. https://doi.org/10.3390/fluids71203752311-5521PURE: 55554746https://doi.org/10.3390/fluids7120375info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:28Zoai:run.unl.pt:10362/150493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:09.034553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery Optimization of Hydrogel Composition based on Rheological Behavior |
title |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery |
spellingShingle |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery Carrêlo, Henrique alginate gellan gum hydrogels Pluronic rheology thermoresponsive Condensed Matter Physics Mechanical Engineering Fluid Flow and Transfer Processes |
title_short |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery |
title_full |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery |
title_fullStr |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery |
title_full_unstemmed |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery |
title_sort |
Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery |
author |
Carrêlo, Henrique |
author_facet |
Carrêlo, Henrique Escoval, André R. Soares, Paula I. P. Borges, João P. Cidade, Maria Teresa |
author_role |
author |
author2 |
Escoval, André R. Soares, Paula I. P. Borges, João P. Cidade, Maria Teresa |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais RUN |
dc.contributor.author.fl_str_mv |
Carrêlo, Henrique Escoval, André R. Soares, Paula I. P. Borges, João P. Cidade, Maria Teresa |
dc.subject.por.fl_str_mv |
alginate gellan gum hydrogels Pluronic rheology thermoresponsive Condensed Matter Physics Mechanical Engineering Fluid Flow and Transfer Processes |
topic |
alginate gellan gum hydrogels Pluronic rheology thermoresponsive Condensed Matter Physics Mechanical Engineering Fluid Flow and Transfer Processes |
description |
projects LA/P/0037/2020. P.S. acknowledges the individual contract CEECIND. 03189.2020. Publisher Copyright: © 2022 by the authors. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-06 2022-12-06T00:00:00Z 2023-03-13T22:27:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/150493 |
url |
http://hdl.handle.net/10362/150493 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carrêlo, H., Escoval, A. R., Soares, P. I. P., Borges, J. P., & Cidade, M. T. (2022). Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery: Optimization of Hydrogel Composition based on Rheological Behavior. FLUIDS, 7(12), [375]. https://doi.org/10.3390/fluids7120375 2311-5521 PURE: 55554746 https://doi.org/10.3390/fluids7120375 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138131151159296 |