Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

• Autor(a) principal: Gomes, Julia do Amaral
• Data de Publicação: 2021
• Outros Autores: Boquett, Juliano André, Silva, Juliana Herrero da, Galera, Marcial Francis, Andrade, Maria Denise Fernandes Carvalho de, Carvalho, Isabella Fernandes, Vianna, Fernanda Sales Luiz, Sgarioni, Eduarda, Trettel, Ana Cláudia Pereira Terças, Ribeiro, Bethânia de Freitas Rodrigues, Oliveira, Thalita Mara de, Faccini, Lavinia Schuler
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/262999
• topic: Exposição materna; Zika virus; Teratógenos; Anomalias congênitas; Variação genética; Polimorfismo genético; Suscetibilidade à doença; Inflamação; Zika virus infection

Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first trimester (p < 0.001) and had mothers with lower educational level (p < 0.001) and family income (p < 0.001). We found higher risk of CZS due the allele rs2297518[A] of NOS2 (OR = 2.28, CI 95% 1.17–4.50, p = 0.015). T allele and TT/CT genotypes of the TNF rs1799724 and haplotypes associated with higher expression of TNF were more prevalent in children with CZS and severe microcephaly (p = 0.029, p = 0.041 and p = 0.030, respectively). Our findings showed higher risk of CZS due ZIKV infection in the first trimester and suggested that polymorphisms in NOS2 and TNF genes affect the risk of CZS and severe microcephaly.