Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13323 |
Resumo: | Texto completo: acesso restrito. p. 93-103 |
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Luz, P. A.Saraiva, R.Almeida, T.Fregoneze, J. B.Castro e Silva, E. de2013-10-30T16:35:46Z20090143-4179http://repositorio.ufba.br/ri/handle/ri/13323v. 43, n. 2Texto completo: acesso restrito. p. 93-103The objective of the present study was to investigate the role of brain kappa-opioid receptors (KOR) in the antidipsogenic effect promoted by third ventricle injections of interleukin-1β (IL-1β). Wistar male rats were submitted to three different, thirst-inducing, physiological conditions: dehydration induced by water deprivation, hyperosmolarity induced by salt-load and hypovolemia induced by polyethylene glycol subcutaneous injection. Third ventricle injections of IL-1β significantly inhibited the increase in water intake observed in those situations. The pharmacological blockade of central KOR by the selective KOR antagonist nor-binaltorphimine (BNI) at different doses significantly inhibited the antidipsogenic effect induced by the central administration of IL-1β in all conditions tested: dehydration, hypovolemia and hyperosmolarity. The central administration of IL-1β failed to induce any locomotor deficit, as verified in an open field test. Stimulation of the central interleukinergic component did not result in any general suppression of ingestive behavior since no change in saccharin intake was recorded during a dessert test in animals receiving central injections of IL-1β. Furthermore, the inhibitory effects of IL-1β on water intake cannot be attributed to sickness-like effects induced by these compounds, since an aversion test excluded this possibility. In summary, the data shown in the present study clearly show that the antidipsogenic effect observed in rats following third ventricle injections of IL-1β depend on the functional integrity of a brain kappa-opioid-dependent component.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-15T14:04:34Z No. of bitstreams: 1 1-s2.0-S014341790900002X-main.pdf: 866064 bytes, checksum: f156079f5d37f1d1fb2c67459a0cde64 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-30T16:35:46Z (GMT) No. of bitstreams: 1 1-s2.0-S014341790900002X-main.pdf: 866064 bytes, checksum: f156079f5d37f1d1fb2c67459a0cde64 (MD5)Made available in DSpace on 2013-10-30T16:35:46Z (GMT). No. of bitstreams: 1 1-s2.0-S014341790900002X-main.pdf: 866064 bytes, checksum: f156079f5d37f1d1fb2c67459a0cde64 (MD5) Previous issue date: 2009http://dx.doi.org/10.1016/j.npep.2008.12.006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInterleukinWater intakeOpioidsKappa-opioid receptorsHypovolemiaDehydrationHyperosmolarityBlockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1βNeuropeptidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01Brasilinfo:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S014341790900002X-main.pdf1-s2.0-S014341790900002X-main.pdfapplication/pdf866064https://repositorio.ufba.br/bitstream/ri/13323/1/1-s2.0-S014341790900002X-main.pdff156079f5d37f1d1fb2c67459a0cde64MD51LICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13323/2/license.txt5371a150bdc863f78dcf39281543bd86MD52TEXT1-s2.0-S014341790900002X-main.pdf.txt1-s2.0-S014341790900002X-main.pdf.txtExtracted texttext/plain47673https://repositorio.ufba.br/bitstream/ri/13323/3/1-s2.0-S014341790900002X-main.pdf.txteea246654b8da9a3ad7ceba315273540MD53ri/133232022-03-10 13:59:54.755oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-10T16:59:54Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
dc.title.alternative.pt_BR.fl_str_mv |
Neuropeptides |
title |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
spellingShingle |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β Luz, P. A. Interleukin Water intake Opioids Kappa-opioid receptors Hypovolemia Dehydration Hyperosmolarity |
title_short |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
title_full |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
title_fullStr |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
title_full_unstemmed |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
title_sort |
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β |
author |
Luz, P. A. |
author_facet |
Luz, P. A. Saraiva, R. Almeida, T. Fregoneze, J. B. Castro e Silva, E. de |
author_role |
author |
author2 |
Saraiva, R. Almeida, T. Fregoneze, J. B. Castro e Silva, E. de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Luz, P. A. Saraiva, R. Almeida, T. Fregoneze, J. B. Castro e Silva, E. de |
dc.subject.por.fl_str_mv |
Interleukin Water intake Opioids Kappa-opioid receptors Hypovolemia Dehydration Hyperosmolarity |
topic |
Interleukin Water intake Opioids Kappa-opioid receptors Hypovolemia Dehydration Hyperosmolarity |
description |
Texto completo: acesso restrito. p. 93-103 |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2013-10-30T16:35:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/13323 |
dc.identifier.issn.none.fl_str_mv |
0143-4179 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 43, n. 2 |
identifier_str_mv |
0143-4179 v. 43, n. 2 |
url |
http://repositorio.ufba.br/ri/handle/ri/13323 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Brasil |
dc.source.pt_BR.fl_str_mv |
http://dx.doi.org/10.1016/j.npep.2008.12.006 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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